Long Covid Weekly #185
A Brief Pause
I’ve really enjoyed writing this newsletter and am grateful to everyone who has followed along. I’m taking a brief pause so I can give it the time and effort needed to make it genuinely worthwhile, with the goal of returning to the full newsletter this fall.
In the meantime, we’ll continue sharing curated quick links and research updates to help you stay abreast of the topics we cover. Thanks, as always, for reading.
Research Quick Links
Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study | Journal of Translational Medicine
Alternative headline: Rapamycin continues to show modest improvement in fatigue in ME/CFS patients, mechanistic pathway proposed
Effect of low-dose naltrexone for long COVID: a systematic review and meta-analysis | BMJ Open
Alternative Headline: Limited evidence suggests LDN may improve fatigue, cognition, sleep, pain and functioning in Long COVID
Efficacy and safety of rivaroxaban, colchicine, and famotidine–loratadine with specialist supportive clinical care for fatigue in patients with post-COVID-19 condition in the UK: a multisite, open-label, randomised controlled trial | The Lancet Infectious Diseases
Alternative Headline: Colchicine and antihistamines show modest improvement in fatigue for Long COVID patients
Metformin and Severe Post-COVID-19 Outcomes Among Individuals with Diabetes Mellitus | medRxiv preprint
Alternative Headline: Metformin is associated with lower mortality from acute COVID-19 and may protect against Long COVID in patients with Type 2 diabetes
Metabolomic Classification of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome via Explainable Ensemble Learning and Pareto-Guided Feature Selection | MDPI
Alternative Headline: Study findings support explainable boosting machine (EBM)-based metabolomic profiling as a validated approach for ME/CFS classification
Biomarkers of post-acute infection syndrome: a systematic literature review | Frontiers in Immunology
Alternative Headline: NF-κB pathway serves as a unifying hub in PAIS mechanistic pathways
Investigating respiratory infection as a post-COVID-19 condition using a large passive surveillance cohort from Track PCC | BMC Infectious Diseases | Springer Nature Link
Alternative Headline: Study finds higher odds of respiratory post-COVID conditions among Medicare/Medicaid users and current smokers
Enrolling and retaining a representative population in the NIH Researching COVID to Enhance Recovery (RECOVER)-Adult Cohort | Research Square Preprint
Alternative Headline: Study finds enrollment easier than retention of a sociodemographically-representative study population
Neurocognitive and psychological symptoms in post COVID-19 patients (PASC24): prospective cohort study protocol | BMJ Open
Alternative Headline: Study plans to chart neurocognitive effects and biomarkers of Long COVID over time
Cognitive Rehabilitation and Functional Outcomes in Long COVID–Related Cognitive Impairment: A Randomized Clinical Trial | Neurology | JAMA Network Open
Alternative Headline: Clinical trial shows that cognitive rehabilitation may effectively treat cognitive impairment in Long COVID
Long-term ocular symptoms following COVID-19 linked to immune dysregulation, dysautonomia and peripheral neuropathy | Nature Communications
Alternative Headline: Study offers biophysical explanation and diagnostic test for light sensitivity, eye pain, reading difficulty and gaze-focusing difficulty for patients with Long COVID
Sustained Reduction in Cardiopulmonary Fitness in Long COVID: A Report from the RECOVER-adult Cohort Study | JACC: Advances
Alternative Headline: Long COVID patients show sustained reductions in cardiopulmonary fitness 2 years after COVID-19
I relate to this and how debilitating it can be. A bit about my story here in case you are curious - https://kaylasalata.substack.com/p/what-was-wrong-with-me
Always grateful to read your newsletter! I hope your rest is fruitful and that you're able to be back offering this really helpful set of resources, plus the plain summaries for those of us with limited energy/time/cognition to follow more!